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SYSTEMETRIC: PHYSIOLOGY SCREEN

SYSTEMETRIC® PHYSIOLOGY SCREEN

asedasciences

Our multi-parametric screens have been developed as a system; multiple technologies function seamlessly as a whole. Our SYSTEMETRIC approach integrates biology, automation and analysis to assess the effect of substances on multiple biological processes within a cell to determine toxic effect or provide a hypothesis for mechanism of action. The sensitivity of our applications also provides support for QSAR related modifications to your compounds, facilitating efforts to recover activity while reducing toxic related effects.

SERVICE FEATURES:

  • Quantitative, multi-parametric human cell-based phenotypic screens
  • Up to 6 parameters measured simultaneously per condition
  • 10-step dose responses
  • High content, high throughput, flow cytometry based application
  • 10,000 cells per condition (e.g., concentration), high statistical robustness
  • Automated analysis: Comparison to known toxins, withdrawn drugs and on-market therapeutics
  • Assessment of the interplay or relationship of various physiological parameters simultaneously
  • Excellent quantification of heterogeneity of cellular effect (e.g., sub-populations, rare events)
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